Which word is synonymous with "appraise"?

The correct choice, "evaluate," is synonymous with "appraise" because both words refer to the act of assessing or determining the value, quality, or significance of something. When one appraises an item, they are essentially evaluating it, often in a formal context such as real estate, art, or performance assessment. The connotation here is one of careful consideration and analysis.

In contrast, the other options do not share this meaning. "Neglect" and "disregard" imply a lack of attention or consideration, which is the opposite of assessing value. "Misjudge" suggests making an incorrect assessment, rather than the act of evaluating or appraising accurately. Therefore, "evaluate" is the most fitting synonym for "appraise."